Brain research bulletinAnimalsBrain-Derived Neurotrophic FactorScopolamineCognitive DysfunctionMice
Traditional herbal medicine Ga-Mi Gongjindan improves muscarinic cholinergic dysfunction through regulation of BDNF/CREB signaling pathway using a scopolamine-induced cognitive impairment of mouse model.
Jong-Kwang Park, Hyeong-Geug Kim, Jong-Suk Lee, Jae-Hong Joo, Ho-Ryong Yoo
Published: 202510.1016/j.brainresbull.2025.111644
Abstract
BACKGROUND: Neurodegenerative diseases, such as Alzheimer's disease (AD), are characterized by progressive memory loss and cognitive dysfunction, often linked to cholinergic system deterioration and hippocampal oxidative stress. Current pharmacologic…
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