Brain research bulletinAnimalsKetamineMaleMiceReceptors
Esketamine relieves depressive-like behaviors in MPTP-induced Parkinson disease mice via GPR109A-dependent reduction of neuroinflammation.
Shu Wang, Wei Song, Yuanyuan Gao, Wei Tan, Lin Ji, Chen Wang
Published: 202510.1016/j.brainresbull.2025.111595
Abstract
BACKGROUND: Depression is a common complication of Parkinson disease (PD). This study investigated whether a single dose of esketamine could alleviate depressive symptoms in an MPTP mouse model by activating G protein-coupled receptor 109 A (GPR109A)…
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