Brain research bulletinAnimalsCyclin-Dependent Kinase 5Stress DisordersPost-TraumaticRoscovitine
Roscovitine alleviates PTSD-like cognitive impairment by inhibiting CDK5-mediated Tau hyperphosphorylation.
Baowen Dong, Mengmeng Chang, Kailu Li, Jinyuan Meng, Lingxue Zhang, Kaiwen Xi, Xiaoyan Wei, Min Cai, Gang Zhu, Dayun Feng
Published: 202510.1016/j.brainresbull.2025.111591
Abstract
BACKGROUND: Post-Traumatic Stress Disorder (PTSD) is a complex cognitive disorder triggered by severe traumatic experiences, currently, lacks effective pharmacological treatments. Recent research has emphasized the pivotal role of hippocampal damage…
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