Brain researchHumansAlzheimer DiseaseGastrointestinal MicrobiomeMendelian Randomization AnalysisGenome-Wide Association Study
Effect of the plasma lipidome, immune cells, inflammatory proteins, gut microbiota, and plasma metabolites on Alzheimer's Disease: A two-sample Mendelian randomized study and mediation analysis.
Zenghui Liu, Lu Kuang, Xiaohui Zhou, Jiaxing Zhao, Qijun Chen, Huayu Yin, Xuehui Liu, Dabin Liu, Shaoguo Wu, Limei Wu
Published: 202510.1016/j.brainres.2025.150009
Abstract
OBJECTIVE: Numerous studies have demonstrated that dysregulated lipid metabolism contributes to the pathological progression of Alzheimer's disease (AD); however, the causal relationship and underlying mechanisms between peripheral plasma lipidome an…
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