Biophysical journal
Systems-level consequences of low raf abundance for egfr-erk signaling.
Sung Hyun Lee, Paul J Myers, Max C Mendrzycki, Kevin S Brown, Leslie M Loew, Alexander Sorkin, Matthew J Lazzara
Published: 202610.1016/j.bpj.2025.12.033
Abstract
RAFs initiate the cascade leading to activation of the extracellular signal-regulated kinases (ERK). In a substantial fraction of cancer cells, RAFs are the least abundant pathway proteins between receptor tyrosine kinases (RTKs) and ERK. In some cas…
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