Biophysical journalRibosomesPeptidesMolecular Dynamics SimulationProtein BiosynthesisStatic Electricity
Advanced coarse-grained model for fast simulation of nascent polypeptide chain dynamics within the ribosome.
Shiqi Yu, Artem Kushner, Ella Teasell, Wenjun Zhao, Simcha Srebnik, Khanh Dao Duc
Published: 202610.1016/j.bpj.2025.10.044
Abstract
The nascent polypeptide exit tunnel (NPET) is a subcompartment of the ribosome that constrains the dynamics of nascent polypeptide chains during protein translation. Simulating these dynamics has been limited by the spatial scale of the ribosome and…
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