Biophysical chemistryDNAMolecular Dynamics SimulationProtein DomainsPolyelectrolytesProtein Binding
Conformational transition of a polycationic hinge domain contributes to DNA binding.
Michael T Harnish, Bill Pham, Avery B Arons, Yingjie Xu, Elias J Fernandez, Tongye Shen
Published: 202610.1016/j.bpc.2025.107531
Abstract
Nuclear receptors (NRs) are multidomain, ligand-activated transcription factors that play critical physiological roles. While the structured DNA-binding domain (DBD) and ligand-binding domain (LBD) have been well characterized, the function of intrin…
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