BoneAnimalsSirtuin 1Cellular SenescenceFemaleMacrophages
ED-71 alleviates OVX-induced osteoporosis by inhibiting macrophage senescence through SIRT1/PGC-1α pathway: A potential therapeutic approach.
Yaqiu Fu, Lingxiao Meng, Minglei Zhang, Lingshuang Li, Hongrui Liu, Wanli Ma, Minqi Li
Published: 202610.1016/j.bone.2025.117737
Abstract
Postmenopausal osteoporosis (PMOP) is a prevalent condition among postmenopausal women, closely linked to estrogen deficiency, aging, and oxidative stress. Cellular senescence, through mechanisms such as the senescence-associated secretory phenotype…
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