BoneAnimalsTuberous Sclerosis Complex 1 ProteinSp7 Transcription FactorMiceKnockout
Loss of Tsc1 in Osterix-expressing cells leads to greater bone mass and strength in mice.
Han Kyoung Choi, Thomas Kim, Xiaoxi Wei, Karl J Jepsen, Yuji Mishina, Nicholas Auyeung, Fei Liu
Published: 202610.1016/j.bone.2025.117695
Abstract
Tuberous sclerosis complex 1 (Tsc1) negatively regulates mTORC1 signaling, but its role in postnatal skeletal development is not fully understood. Previous studies using various Cre drivers to target osteoblasts or mesenchymal lineage cells have gene…
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