Bioorganic & medicinal chemistry letters
Inhibitory effects against Trypanosoma cruzi, Leishmania infantum and trypanothione reductase of N1,N4-bisbenzylbutane-1,4-diamines.
Otília Höeller Guarnieri, Mariza Gabriela Faleiro de Moura Lodi Cruz, Daniela de Melo Resende, Carime L M Pontes, Igor Vivan Roberto, Luiza Schmidt D'Agostini, Bertha Chithambo, Niklas Ehlenz, Xavier Siwe-Noundou, Rui W M Krause, Maique W Biavatti, Jaya R Lakkakula, Nilesh Shirish Wagh, Mario Steindel, Till Opatz
Published: 202610.1016/j.bmcl.2026.130541
Abstract
Trypanosoma cruzi and Leishmania spp. are the protozoan parasites responsible for Chagas disease and leishmaniasis. The treatment of these neglected diseases relies on repurposed drugs and faces several challenges including high toxicity, and the eme…
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