Bioorganic & medicinal chemistry letters
Monaprenylindole A, a prenylated indole derivative from marine-derived Streptomyces sp., accelerates wound healing through the enhancement of keratinocyte motility via the modulation of cytoskeletal remodeling and growth factor pathways.
Eun-Young Lee, Mücahit Varlı, Hiyoung Kim, Soyeong Kim, Seongeun Kang, Jungwook Chin, Hongchan An, Hangun Kim, Sang-Jip Nam
Published: 202610.1016/j.bmcl.2026.130539
Abstract
Wounds pose significant healthcare challenges, prompting the need for novel therapeutics with pro-regenerative potential. Natural products from marine-derived actinomycetes are a promising source of small bioactive molecules. The first total synthese…
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