Bioorganic & medicinal chemistry letters
Second generation PSMA-targeted turn-on probe for imaging cargo release in prostate cancer cells.
Nooshin Mesbahi, Brenna C McAllister, Hosog Yoon, Aaron T Hendricksen, Melody D Fulton, Leslie A Caromile, Clifford E Berkman
Published: 202510.1016/j.bmcl.2025.130530
Abstract
Targeted payload release in cancer cells can be modulated by tuning both the linker, spacer, and the payload chemistries. In previous studies, a PSMA-targeted probe incorporating a 7-amino-4-methylcoumarin (AMC) payload and a PEG linker resulted in p…
Preview only. Read the full abstract at the source