Bioorganic & medicinal chemistry letters
Evaluation of the efflux inhibitory potential of aminopyrazole derivative to restore azole sensitivity in Candida albicans.
Vineetha K Unnikrishnan, Niranjana Sri Sundaramoorthy, Ramaravinth Manivannan, Markabandhu Shanthi, Divya Prakash Gnanadhas, Soundarya Alexander, Venkatasubramanian Ulaganathan, Ramesh Subburethinam, Saisubramanian Nagarajan
Published: 202510.1016/j.bmcl.2025.130529
Abstract
Candida albicans is an opportunistic fungus that causes infections in people with weakened immune system. Candida has the propensity to gain drug resistance by mutation, and its ability to extrude antifungals through drug transporters. Efflux pump in…
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