Bioorganic & medicinal chemistry letters
Alternariol from the endophytic fungus Alternaria sp. S4 acts as a membrane-targeting bactericidal agent against Staphylococcus aureus.
Yanlin He, Yuwan Zhang, Wei Wang, Chaoyong Cui, Qianyun Hao, Hongguan Xie, Rui Yang
Published: 202510.1016/j.bmcl.2025.130513
Abstract
The endophytic fungus Alternaria sp. S4, derived from Ruta graveolens, shows significant antimicrobial potential, but its active components and mode of action require clarification. Through bioassay-guided fractionation, alternariol (1) and alternari…
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