Bioorganic & medicinal chemistry letters
AI-guided design of cyclic peptide binders targeting TREM2 using CycleRFdiffusion and experimental validation.
Sungwoo Cho, Renjie Zhu, Katarzyna Kuncewicz, Hongliang Duan, Moustafa Gabr
Published: 202510.1016/j.bmcl.2025.130512
Abstract
Triggering receptor expressed on myeloid cells 2 (TREM2) plays a central role in regulating microglial function in the central nervous system and has emerged as a promising therapeutic target for Alzheimer's disease. Despite advances in antibody-base…
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