Bioorganic & medicinal chemistry letters
Identification of a novel Songorine derivative as a potent NLRP3 inflammasome inhibitor.
Runqin Liu, Qiang Zhang, Miao Xian, Qifeng Chen
Published: 202510.1016/j.bmcl.2025.130511
Abstract
As a key intracellular pattern-recognition receptor, NLRP3 senses diverse pathogen- and damage-associated molecular patterns (PAMPs and DAMPs), initiating inflammasome assembly and pyroptotic cell death. Aberrant NLRP3 activation contributes to vario…
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