Bioorganic & medicinal chemistry lettersProtein Kinase InhibitorsAgammaglobulinaemia Tyrosine KinaseStructure-Activity RelationshipHumansPyridines
Discovery of novel imidazo[4,5-b]pyridine derivatives as noncovalent reversible Bruton's tyrosine kinase inhibitors.
Yeojeong Kim, Jingyang Sun, Kyoungyim Lee, Soobin Kim, Danbi Lee, Bomi Park, Yeji Lee, Inah Hwang, Jae-Sang Ryu
Published: 202610.1016/j.bmcl.2025.130497
Abstract
Bruton's tyrosine kinase (BTK) has emerged as a validated therapeutic target for B-cell malignancies and autoimmune disorders, and covalent BTK inhibitors have demonstrated remarkable clinical efficacy. However, because of concerns regarding their of…
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