Bioorganic & medicinal chemistry lettersNuclear Receptor Subfamily 1Group FMember 3Structure-Activity RelationshipHumans
A potent and selective RORγ inhibitor for the treatment of autoimmune diseases.
Taku Ikenogami, Masahiro Yokota, Shingo Fujioka, Naoki Ogawa, Masato Noguchi, Akihiro Nomura, Tsuyoshi Adachi, Yoshiaki Katsuda, Kojo Arita, Naoki Miyagawa, Yusuke Aratsu, Kota Asahina, Paul Crowe, Haiyan Tao, Scott Thacher
Published: 202610.1016/j.bmcl.2025.130494
Abstract
Retinoic acid receptor-related orphan receptor γ (RORγ) is a master transcriptional regulator of Th17 cell differentiation as well as of the production of pro-inflammatory cytokines such as IL-17 and IL-22. Its critical role in Th17 cell function and…
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