Bioorganic & medicinal chemistry lettersNon-alcoholic Fatty Liver DiseaseHumansAnimalsMiceHEK293 Cells
Exploring the therapeutic potential of deuterated PPARγ agonists for NASH.
Xudong Pang, Dawei Cui, Ruifeng Liu, Binhua Lv, Cheng-Yun Wang
Published: 202610.1016/j.bmcl.2025.130489
Abstract
NASH represents an increasingly prevalent chronic liver disease, and TZDs are investigated as a potential therapeutic strategy. However, the inherent enolic structure of TZDs leads to enantiomeric instability and racemization, often requiring their u…
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