Bioorganic & medicinal chemistry lettersPyridinesProtein Kinase InhibitorsProto-Oncogene Proteins B-rafMolecular Docking SimulationAdamantane
LXH254 hybrid with adamantane: synthesis and in vitro evaluation of 2,4,6-trisubstituted pyridine derivative Z-001 containing adamantyl moiety as a novel B-RAF inhibitor.
Wei Fan, Meina Li, Yeming Wang
Published: 202610.1016/j.bmcl.2025.130481
Abstract
In this study, 2,4,6-trisubstituted pyridine derivative Z-001 containing adamantyl moiety was designed through the hybridization strategy of LXH254 and adamantane. A new and effective synthetic route was established to achieve the synthesis of Z-001…
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