Bioorganic & medicinal chemistry lettersHumansCathepsinsFluorescent DyesCysteineAnimals
Chemiluminescent probes for imaging cysteine cathepsin activity.
Jiyun Zhu, Sara Gutkin, Shiyu Chen, Shih-Po Su, Hai Phan, Doron Shabat, Matthew Bogyo
Published: 202610.1016/j.bmcl.2025.130480
Abstract
The cysteine cathepsins are a family of proteases that are widely expressed in diverse cell types. However, because their activity is highly upregulated at sites of inflammation, they are ideal targets for imaging a range of disease pathologies inclu…
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