Bioorganic & medicinal chemistry lettersAlzheimer DiseaseNeuroprotective AgentsAmyloid beta-PeptidesSesquiterpenesAnimals
Structural modification of atractylenolides: synthesis and evaluation of derivatives with potent anti-Aβ aggregation and neuroprotective activities against Alzheimer's disease.
Tiancheng Sun, Zhonghua Li, Bingyu Xiao, Jige Yang, Mengyu Han, Jiaxin Zhang, Sijia Liu, Jinlian Ma, Pan Wang
Published: 202610.1016/j.bmcl.2025.130478
Abstract
Alzheimer's disease (AD), a progressive neurodegenerative disorder characterized by β-amyloid (Aβ) deposition, hyperphosphorylated Tau tangles, and neuronal loss, lacks effective disease-modifying therapies. Herbal medicines like Atractylodes macroce…
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