Bioorganic & medicinal chemistry letters
Design, synthesis, and antitumor activity study of novel oleanolic acid structural derivatives targeting c-Kit.
Xuan Zhou, Junjiao Ma, Liangfeng Zhang, Zibo Zhao, Ziwen Xu, Yanqiu Meng
Published: 202510.1016/j.bmcl.2025.130433
Abstract
Oleanolic acid (OA) is a pentacyclic triterpenoid, which inhibits tumor cell proliferation. In this study, OA was selected as the lead compound, and computer-aided drug design was used to develop novel derivatives. Structural modifications were made…
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