Bioorganic & medicinal chemistry letters
Targeted design, synthesis, molecular simulation, ADME-T and in-vitro anticancer assessment of phenyl-substituted-thioxo-tetrahydro-pyrimidin-benzenesulfonamide derivatives as potential BRAFV600E/WT inhibitors.
Ankit Kumar Singh, Vineet Prajapati, Adarsh Kumar, Vimlendu Kumar Sah, Prateek Pathak, Mashooq A Bhat, Mohamed A Al-Omar, Amita Verma, Pradeep Kumar
Published: 202510.1016/j.bmcl.2025.130431
Abstract
BRAF is one of the most commonly mutated oncogenes in human cancers, with more than 90 % of mutations occurring at codon 600. Among these, BRAFV600E is the most prevalent, accounting for nearly 90 % of all BRAF codon 600 mutations, while the less fre…
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