Bioorganic & medicinal chemistry letters
Design and synthesis of guanidino derivatives of benzoate esters as SIRT6 inhibitors.
Yongzhi Ma, Minni Ding, Kewang Yu, Siyu Wang, Siyuan Wang, Hao Cao, Huiming Hua, Dahong Li
Published: 202510.1016/j.bmcl.2025.130430
Abstract
SIRT6 is a key member of the Sirtuin family and plays a crucial role in regulating cellular metabolism, maintaining genomic stability, and influencing the aging process. SIRT6 inhibitors have garnered significant attention due to their potential ther…
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