Bioorganic & medicinal chemistry letters
Development and bio-evaluation of novel indolizine derivatives in FLT3 mutant acute myeloid leukemia cells.
Qianlu Xing, Jiangdong Li, Yanjiao Shen, Lu He, Xiaojuan Ma, Pei Huang, Qiang Huang, Yan Chen
Published: 202510.1016/j.bmcl.2025.130429
Abstract
Acute myeloid leukemia (AML) is a highly malignant blood tumor, and FLT3 serves as an important molecular target for the treatment of AML. Currently, FLT3 inhibitors still have issues of drug resistance and unsatisfactory clinical efficacy in the tre…
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