Bioorganic & medicinal chemistry
Harnessing N-substituted benzotriazole scaffolds as potent methionine aminopeptidase inhibitors: from chemical design to cellular efficacy.
Vivekananda Saha, Ajinur Hossain, Khairud Zaman Miraj, Nasim Sepay, Souvik Sarkar, Subarna Roy, Jungkyun Im, Goutam Biswas
Published: 202610.1016/j.bmc.2026.118553
Abstract
Herein, we present the synthesis, characterization, and biological evaluation of twenty-five N-substituted benzotriazole derivatives as potential anticancer agents targeting methionine aminopeptidase (MAP) enzymes. The compounds were synthesized foll…
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