Bioorganic & medicinal chemistry
Therapeutic targeting of CDK12: a medicinal chemistry perspective.
Feifei Wang, Hongxue Dai, Kuanxin Wan, Mingliang Wang
Published: 202610.1016/j.bmc.2026.118552
Abstract
CDK12 (Cyclin-dependent kinase 12) is a cyclin-dependent kinase that regulates gene transcription by phosphorylating the C-terminal domain of RNA polymerase II, playing a crucial role in maintaining genomic stability. Mutations or alterations in the…
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