Bioorganic & medicinal chemistryMycobacterium tuberculosisQuinolonesDrug DesignHumansAntitubercular Agents
Design, synthesis and biological evaluation of novel quinolinone derivatives as DprE1 inhibitors against Mycobacterium tuberculosis.
Guoquan Wan, Chao Gao, Fei Teng, Qifan Tang, Jumei Zeng, Luoting Yu
Published: 202610.1016/j.bmc.2026.118551
Abstract
Tuberculosis remains a global health crisis, exacerbated by the emergence of drug-resistant strains and limitations of current therapies. Aiming to the essential enzyme DprE1 in Mycobacterium tuberculosis, we designed and synthesized 34 novel quinoli…
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