Bioorganic & medicinal chemistryHumansNeoplasmsImmunotherapyProtein Kinase InhibitorsProtein Serine-Threonine Kinases
Targeting HPK1 for cancer immunotherapy: An update on recent medicinal chemistry advances.
Yiyun Song, Zepeng Liao, Xiang Ni, Dexiang Wang, Zhihao Qi, Qi Miao, Sheng Jiang, Kuojun Zhang
Published: 202610.1016/j.bmc.2026.118546
Abstract
Hematopoietic progenitor kinase 1 (HPK1), a pivotal negative regulator of immune signaling pathways, represents an attractive therapeutic target for cancer immunotherapy. Supported by encouraging preliminary clinical data showing promising efficacy a…
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