Bioorganic & medicinal chemistryAPOBEC-3G DeaminaseHumansvif Gene ProductsHuman Immunodeficiency VirusHIV-1
The development of anti-HIV agents targeting APOBEC3G/Vif axis.
Qiqi Bao, Jiajia Wen, Fengjiao Xiang, Ling Ma, Jiwei Ding, Xinlu Wang, Shan Cen, Jinming Zhou
Published: 202610.1016/j.bmc.2025.118519
Abstract
The human host restriction factor APOBEC3G (Apolipoprotein B mRNA editing enzyme-catalytic polypeptide-like 3G, A3G) potently inhibits the replication of human immunodeficiency virus type 1 (HIV-1). To counteract this restriction, HIV-1 encodes the v…
Preview only. Read the full abstract at the source