Bioorganic & medicinal chemistryAnthelminticsAntifungal AgentsDrug DesignStructure-Activity RelationshipQuinazolinones
Design, synthesis, and biological evaluation of a focused pyrrolo- and pyrido-quinazolinone natural products-templated library for anti-fungal and anthelmintic activities.
Romina E D'Almeida, Paulina Chen, Yanchang Huang, Emily Goetz, Vamshikrishna Reddy Sammeta, Bo Yang, Reeta P Rao, Sivappa Rasapalli, Mostafa A Elfawal
Published: 202610.1016/j.bmc.2025.118517
Abstract
A focused pyrrolo- and pyrido-quinazoline natural products-templated library has been designed and synthesized using two novel synthetic approaches: an aza-Nazarov approach and a Dieckmann cyclization strategy. This privileged scaffold-based collecti…
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