Bioorganic & medicinal chemistryIndoleamine-Pyrrole 23-DioxygenaseAnimalsAntidepressive Agents
Novel indole-based indoleamine 2,3-dioxygenase-1 (IDO1) inhibitors: design, synthesis, and antidepressant evaluation.
Juan Zhang, Wen-Jing Gao, Yu-Xi Zheng, Jia-Dong Shao, Nai-Yu Zhang, Wei Guo, Shuai Wang, Qing Zhao, Kongkai Zhu, Ming Gao, Jin-Hai Yu, Ning Meng, Cheng-Shi Jiang
Published: 202610.1016/j.bmc.2025.118503
Abstract
Indoleamine 2,3-dioxygenase-1 (IDO1) has emerged as a promising therapeutic target for antidepressant development. The present study performed scaffold hopping-based structural optimization of a known benzimidazole-derived IDO1 inhibitor C-0 (20.20 ±…
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