Bioorganic & medicinal chemistryHumansAlzheimer DiseaseCholinesterase InhibitorsTacrineAmyloid beta-Peptides
Pyranotacrines as prospective multi-target compounds against Alzheimer's disease.
Salma Fares, Walaa M El Husseiny, Khalid B Selim, Mohammed A M Massoud
Published: 202610.1016/j.bmc.2025.118480
Abstract
A series of tacrine-based 4-H-pyran derivatives were synthesized and biologically estimated as multifactorial ligands against Alzheimer's disease. Pyranotacrines were characterized by having the main core tacrine (ChE inhibition) and tetrahydro-4H-py…
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