Bioorganic & medicinal chemistryStructure-Activity RelationshipIndolequinonesEnzyme InhibitorsQuinone ReductasesHumans
Indolequinone inhibitors of NRH:quinone oxidoreductase 2. Further structure-activity relationships.
Tatiana A Dias, David Siegel, David Ross, Christopher J Moody
Published: 202610.1016/j.bmc.2025.118468
Abstract
An improved route to the indolequinone pharmacophore is described based on the reaction of bromobenzoquinones with enamines. Through the implementation of small changes in the reaction conditions, the reaction conditions were much improved with quant…
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