Bioorganic & medicinal chemistryMast CellsAnimalsReceptorsIgEAnti-Allergic Agents
Down-regulation of FcεRI expression on mast cells leads anti-allergic effect.
Chiaki Tanaka, Kazuki Ujiie, Mai Kume, Nobutoshi Murakami, Satoru Tamura
Published: 202610.1016/j.bmc.2025.118442
Abstract
The high-affinity IgE receptor (FcεRI) is essential for Type-I allergic syndromes represented by hay fever, but any anti-allergic drugs targeting FcεRI haven't been approved. We have been engaged in search for the inhibitors against FcεRI expression…
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