Bioorganic & medicinal chemistryHumansApoptosisCyclin-Dependent Kinase 4Antineoplastic AgentsDrug Design
Design, synthesis, and biological evaluation of new triazolopyridazine-based derivatives as cyclin dependent kinase-4 inhibitors with apoptosis-inducing and tumor-suppressive effects.
Eman A El-Khouly, Eman M Ahmed, Madiha K El-Sobky, Shaymaa G Ibrahim, Khaled M Gouda, Ahmed A M Ibraheem
Published: 202610.1016/j.bmc.2025.118434
Abstract
A new series of triazolopyridazine-based derivatives were designed and synthesized. Biological targets were predicted for compounds IIIa-k, IVa-c, V, and VI using Swiss Target Prediction combined with pharmacological network analysis. Functional anno…
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