British journal of anaesthesiaHumansMaleCrystalloid SolutionsEndotoxemiaAdult
The effects of balanced crystalloid versus plasma on endothelial injury, systemic inflammation, and coagulation in experimental endotoxaemia: a randomised human volunteer study.
Daan P van den Brink, Bashar N Hilderink, Derek J B Kleinveld, Robert B Klanderman, Inge Pareyn, Karen Vanhoorelbeke, Philip C Spinella, Nicole P Juffermans
Published: 202610.1016/j.bja.2025.08.060
Abstract
BACKGROUND: During shock, neutrophil-mediated glycocalyx degradation can lead to exposure of the procoagulant endothelial surface and consequent organ injury. Resuscitation using crystalloid fluids may augment this endothelial damage, while resuscita…
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