British journal of anaesthesiaAnimalsTriple Negative Breast NeoplasmsMiceReceptorsOpioid
κ-Opioid receptor activation suppresses triple-negative breast cancer progression by inducing urea cycle dysfunction and mitochondrial damage in vitro and in mice.
Yumiao Shi, Yiying Tao, Zhiying Pan, Xiaoqiang Wang, Chaojin Zhang, Shujing Zhou, Daxiang Wen, Guojun Qian, Weifeng Yu, Jie Tian
Published: 202510.1016/j.bja.2025.07.093
Abstract
BACKGROUND: Triple-negative breast cancer (TNBC) is an aggressive malignancy with limited therapeutic options. Opioids are commonly used for perioperative and chronic pain management in patients with cancer. Notably, the κ-opioid receptor (KOR) has s…
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