Bioresource technologyErythromycinEscherichia coliPlasmidsChromosomesBacterial
Reusable target-site toolkit for large-fragment (56.2 kilobases) chromosomal integration to enhance erythromycin biosynthesis in Escherichia coli.
Zhanguang Feng, Guangyi Wang, Zhifeng Liu, Yuhan Wu, Jiangming Zhu, Yong Wang
Published: 202610.1016/j.biortech.2025.133917
Abstract
Erythromycin, a broad-spectrum antibiotic, is a prototypical polyketide produced via heterologous biosynthesis in Escherichia coli. However, the instability of plasmid‑encoded genes within the erythromycin biosynthetic pathway, coupled with limited i…
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