Bioresource technologyEscherichia coliPhotochemotherapyCalcium PhosphatesPhycocyaninPhycobilins
Engineering a living therapeutic: calcium phosphate-mineralized phycocyanobilin-producing E. coli as a self-contained photodynamic system.
Yifan Wei, Nana Pan, Jingjing Du, Chao Wang, Xin Chen, Jin-Ao Li, Li Lu, Baosheng Ge, Fang Huang, Xiaojuan Wang
Published: 202610.1016/j.biortech.2025.133579
Abstract
The complex synthesis, purification, and delivery of photosensitizers remain major bottlenecks for clinical photodynamic therapy (PDT). Here, we develop PCB@Ecoli@CaP, an engineered Escherichia coli-based living therapeutic that autonomously biosynth…
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