Bioresource technologyKetonesStereoisomerismSubstrate SpecificityProtein EngineeringOxidation-Reduction
Rational engineering of ketoreductase SsSDR1 for stereoselectivity inversion toward 3-N-substituted azacyclic ketones.
Xiao Qiu, Changli Che, Lichun Tang, Bin Qin, Wenhe Zhang, Xian Jia, Song You
Published: 202610.1016/j.biortech.2025.133572
Abstract
The stereocomplementary reduction of 3-N-substituted azacyclic ketones using ketoreductases remains inherently challenging, especially for the simultaneous achievement of strict stereoselectivity reversal toward both five- and six-membered ring subst…
Preview only. Read the full abstract at the source