Bioresource technologySaccharomyces cerevisiaePentacyclic TriterpenesCytochrome P-450 Enzyme SystemMetabolic EngineeringOxidation-Reduction
Cofactor-coupled cytochrome P450 engineering enables high-level biosynthesis of asiatic acid in Saccharomyces cerevisiae.
Yuan Zhu, Xiaoguang Yan, Weiguo Li, Yuan Zhong, Jianjun Qiao, Guang-Rong Zhao
Published: 202610.1016/j.biortech.2025.133558
Abstract
Asiatic acid (ASA) is a pharmacologically active triterpenoid and traditionally obtained from plant Centella asiatica via solvent extraction processes that are inefficient and difficult to scale up due to the low content of ASA and the seasonal varia…
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