Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Targeting frataxin deficiency in DRG neurons and fibroblasts: omaveloxolone restores metabolic and iron balance to reduce ferroptosis.
Marta Portillo-Carrasquer, Arabela Sanz-Alcázar, Begoña Sánchez-López, Fabien Delaspre, Maria Pazos-Gil, Luiza Oliveira-Jorge, Laia Castells-Roca, Jordi Tamarit, Joaquim Ros, Elisa Cabiscol
Published: 202610.1016/j.biopha.2026.119031
Abstract
Friedreich ataxia (FA) is a rare, multisystemic neurodegenerative disorder caused by a deficiency of the mitochondrial protein frataxin. It is characterized by degeneration of the large sensory neurons in the dorsal root ganglia (DRG) and spinocerebe…
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