Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Solvent osmolarity and viscosity regulate lymph node pharmacokinetics and perinodal dynamics in lymphatic drug delivery.
Taiki Shimano, Daiki Nagamatsu, Ryoichi Fukumura, Ariunbuyan Sukhbaatar, Shiro Mori, Tetsuya Kodama
Published: 202610.1016/j.biopha.2026.118985
Abstract
The lymphatic drug delivery system (LDDS) offers a promising strategy for treating lymph node (LN) metastases through direct administration of therapeutic agents into the sentinel LN, enabling subsequent delivery to downstream nodes via lymphatic ves…
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