Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapieAnimalsAdenosineInsulin-Secreting CellsAdenosine DeaminaseDiabetes Mellitus
AMP deaminase-2- and adenosine deaminase-mediated disposal of β-cell intracellular adenosine protects against multiple low-dose streptozotocin-induced type 1 diabetes.
Kailash Singh, Tongjian Zhao, Anongnad Ngamjariyawat, Kina Adjieva, Mudhir Shekha, Ronja Andersson, Averina Octaxena Aslani, Martin Blixt, Zhengkang Luo, Stellan Sandler, Nils Welsh
Published: 202610.1016/j.biopha.2025.118914
Abstract
OBJECTIVE: To evaluate the importance of AMPD2 and ADA, two adenosine disposal enzymes, for β-cell survival and the development of T1D. METHODS: The nucleotide metabolism in EndoC-βH1 cells was compared with that of α-TC1-6 cells using HPLC and enzym…
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