Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapieAnimalsHepatolenticular DegenerationCopperLiverHepatocytes
Rapid transcellular hepatic copper depletion by ARBM-101 rescues severe liver damage in Wilson disease rodents.
Jonas Engler, Eun-Jung Kim, Dasol Kim, Noreene M Shibata, Emilie Munk Lynderup, Mikkel H Vendelbo, Banu Akdogan, Judith Sailer, Adriana Fontes, Carola Eberhagen, Tamara Rieder, Quirin Reinold, Hongjae Lee, Dongsik Park, Chunwon Jung
Published: 202510.1016/j.biopha.2025.118867
Abstract
In Wilson disease (WD), excess copper provokes hepatocyte death due to impaired copper excretion, ultimately causing either acute or chronic liver damage. Current therapeutic compounds fail to reduce hepatic copper near to physiological levels, leavi…
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