Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapieGene EditingHumansCRISPR-Cas SystemsHEK293 CellsAnimals
Peptide-assisted lipofection enables efficient non-viral delivery of large CRISPR/Cas9 constructs for genome editing applications.
Yeong Chae Ryu, Gang Bao, Byeong Hee Hwang
Published: 202510.1016/j.biopha.2025.118838
Abstract
Efficient and safe delivery of large genetic constructs such as CRISPR/Cas9 plasmids remains a critical bottleneck in gene therapy. In this work, the peptide-assisted lipofection (PAL) system was developed as a breakthrough non-viral vector for gene…
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