Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapieHumansB7 AntigensB-Cell Maturation AntigenMultiple MyelomaReceptors
Dual targeting of BCMA and B7-H3 with CAR T cells and bispecific protein engagers enhances anti-myeloma activity.
Naeramit Sontayananon, Pornpimon Yuti, Nunghathai Sawasdee, Seiji Okada, Mutita Junking, Jatuporn Sujjitjoon, Pa-Thai Yenchitsomanus
Published: 202510.1016/j.biopha.2025.118820
Abstract
BACKGROUND: B cell maturation antigen (BCMA)-directed chimeric antigen receptor (CAR) T cells have shown remarkable activity in relapsed/refractory multiple myeloma (R/R MM). However, therapeutic resistance often arises due to antigen heterogeneity a…
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