Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapieHumansLung NeoplasmsAnimalsRNASmall Interfering
siRNA-based therapeutic candidate targeting PRDM2 for inhibition of lung cancer progression.
Sanjay Kumar, Md Zubbair Malik, Maya Chaturvedi, Mohit Mishra, Marzia Di Donato, Amelia Casamassimi, Ciro Abbondanza, Patrizia Gazzerro, Chuong Nguyen, Nicole N Nuñez, Somdutta Sen, Brad Niles, Rupesh Chaturvedi
Published: 202510.1016/j.biopha.2025.118807
Abstract
Lung cancer is the leading cause of tumor-related deaths worldwide. In over 70 % of patients, the positive regulatory domain 2 (PRDM2) gene, which encodes the tumor suppressor RIZ1 and the oncogenic RIZ2 isoforms, is dysregulated, promoting tumor pro…
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